1960 - Mid Atlantic
1. Swim past the plane wreckage and then walk up the stairway.
2. Enter the door at the top of the steps and proceed down the second stairway.
3. Pull the bathysphere lever inside the pod to submerge and get to Rapture.
4. Grab the radio and then exit the pod.


Bathysphere Station
1. Keep moving, pick up the wrench up ahead and then use it to smash a larger opening in the wall.
2. Move out of the way to avoid the burning sofa that tumbles down the stairs.
3. Bludgeon the thuggish splicer with your wrench and then search his body for items.
4. Go up the stairs nearby to get your first plasmid, the Electro Bolt, and then use it on the switch that has short circuited and leave the area.
5. Walk through the chunk of the plane that impales the tube and then kill the two splicers up ahead.
6. Put the splicer who's on fire out of his misery and enter the elevator.

Kashmire Restaurant / Footlight Theater
1. Take out the female splicer and pull the pistol out of her baby carriage.
2. Go downstairs to the cocktail lounge and get ready to fight several splicers.
3. Make sure you get the cash scattered throughout the kitchen and then go back upstairs.
4. Move through the men's restroom to get to the Footlight Theater and go downstairs to exit the theater.


Rapture Metro
1. Zap the water to electrocute the splicers standing in it and search the corpses for items.
2. Move towards Neptune's Bounty and kill off the swarm of enemies that come after you.
3. Don't let the flamethrower near the entrance to Neptune's Bounty burn you to death.
4. Head to the Medical Pavilion.

Neptune's Bounty
1. Continue onward to the lower wharf, defeat the Big Daddy there, and extract the ADAM from the little sister.
2. If you've been saving the little sister's up until this point, you'll be notified of Tennenbaum's first reward for you (200 ADAM and Hypnotize Big Daddy Plasmid) and which will be inside a teddy bear near a gatherer's garden in Fontaine Fisheries.


Fontaine Fisheries
1.. Before they let you into Fontaine Fisheries, you need to find a camera and take photos of 3 spider splicers (other than the first one you encounter since you won't have a camera at this point).
2. Get the camera for your research inside the interrogation room, drop down into the upper wharf.
3. One spider splicer is in the upper wharf, another is in Fighting Mcdonagh's Tavern, and the last is in the Jet Postal Substation.
4. Once you have taken all three photos, head back to Fontain Fisheries and you'll be able to go in only you'll have to relinquish your weapons, but don't worry too much because you'll get them back shortly.
5. Remember to user your Incinerate! plasmid to melt away chunks of ice that hold items and block doors.
6. Kill Peach Wilkins and the splicers you encounter and then head towards the submarine bay, picking up your weapons in the meantime.


Smuggler's Hideout
1. Proceed through the flooded cave and make your way to the hatch to let Atlas in.
2. Kill off the numerous splicers in the area and then leave the loading dock.


Arcadia
1. Start making your way towards the Metro Station, first by going through the tea garden.
2. You'll come into contact with a new kind of splicer, the Houdini splicer, which can vaporize instantaneously and move around in this state.
3. Keep moving forward and you'll eventually get to the Arcadia Glens. 4. Go to the lower rolling hills.
5. You'll eventually have to collect a rose specimen and then bring it back to Julie Langford.


Langford Labs
1. Once you put the rose in the Pneumo Tube, Langford will let you into the lab.
2. Andrew Ryan is one step ahead of you again, and once you find out what I'm talking about, go inside Langford's lab and search the place, writing down the 9457 number she wrote on the window.
3. Use the number to open her safe, which contains several items including the Market Key.
4. You'll also be able to pick up a Chemical Thrower weapon which is on her desk.
5. Next on your plate is inventing the Lazarus Vector, which you'll need 7 distilled waters, 7 enzyme samples, and 7 chloraphyll solutions.
6. Head to the Farmer's Market for these items.

Farmer's Market / Langford Labs
1. Search for the items you need to create the Lazarus Vector, on the corpses of splicers and in your surroundings.
2. Once you get to where the bees are kept, be sure to turn on the smoke to scare away the bees before you search the area.
3. Gathered the required enzymes in this area and then move on to the winery to collect the distilled water and the chloraphyll solutions.
4. Head back to Langford's lab and use the U-Invent machine in her office to make the Lazarus Vector.
5. After creating the Vector, put it in the Misting Machine which is also inside Langford's office, and then go seal off the entrance to the lab to stall Ryan's minions.
6. You'll need to battle the massive group of splicers Ryan sends you way to buy time.
7. Once you're done, return to Langford's office and deploy the Lazarus Vector.

Fort Frolic
1. Enter the bathysphere to go to Fort Frolic and when you get there go to Hephaestus.
2. Next go to Fleet Hall to find Sander Cohen and take the elevator you come to.
3. Take a photograph of the pianist after he is dead, find Cohen's masterpiece, and then place the photo in one of the frames.
4. Pick up the Crossbow on Cohen's masterpiece.
5. Kill Martin Finnegan, Silas Cobb, and Hector Rodriguez (one is located in the giant freezer area, another is in the record shop, and the last is in the garden store), take photos of their corpses and place the photos in the remaining empty frames of Cohen's masterpiece.

Hephaestus
1. Go to Andrew Ryan's office and make your way through the Hephaestus Core area to get to the Heat Loss Monitoring area, killing splicers you encounter on the way.
2. Once you've searched the Heat Loss Monitoring, go to Kyburz's Workshops and then search for his device, which turns out to be an unfinished bomb.
3. Finish assembling Kyburz's Emp Bomb by collecting 4 R-34 Wire Clusters which can be found on the corpses of Big Daddys (you'll have to kill a few) and 2 cans of Ionic Gel (which aren't hard to find--just backtrack a bit).
4. The third component of the Emp Bomb is one Nitroglycerin Charge (which is located in Kyburz's office) and you have to acquire this last after you've already put the R-34 Wire Clusters and Ionic Gel on the bomb itself.
5. To get into Kyburz's office, you'll need to hack the combination lock on his door.
6. Once inside, shoot all the trap bolts that are in your way.
7. There is a button on the side of the desk in his office that you need to press to open the case holding the Nitroglycerin Charge.
8. Put the Charge on the bomb to complete it and then make your way to the core where you need to place the bomb.

The Core
1. Where you are inside the Geothermal Control area, turn the Magma Release Valve to redirect the magma flow.
2. You'll be constantly interrupted by splicers, but keep pressing and holding a to turn the valve in between killing off your distractions.
3. Pull the lever in front of the core to lower it, and then place the bomb on it to overload the core.
4. Now you must go and destroy Ryan's Mag-Locks.

Rapture Central Control1. Time to kill Andrew Ryan.
2. Head up the stairwell and go through the crawlspace.
3. After you beat Ryan to a bloody pulp with his own golf club, go over and press the button to override the self destruct.
4. Quickly make your way to Olympus Heights.


Olympus Heights Sewers1. Find the piece needed, repair the gate crank socket, and then turn the wheel.
2. Go and search Suchong's apartment and then get the Lot 102 Remedy.
3. You'll learn from Paparazzi's diary that the code for the elevator is 5744, so enter it into the keypad and ride the elevator up to the home of Frank Fontaine.
4. Get the Lot 192 and you'll discover that you need to get a second dosage of Lot 192, so start heading for it.
5. Run towards Point Prometheus, and don't even try to fight the splicers and security bots that attack you--just run.
6. Enter the bathysphere to go to Point Prometheus.


Point Prometheus
1. You need to become a Big Daddy by smelling like one (in Little Wonders), sounding like one (in Optimized Eugenics), and looking like one (in Fallsate Armored Escorts).
2. First grab the three Big Daddy pheromones in Little Wonders.
3. Go into Fallsate Armored Escorts and get yourself a Big Daddy suit, a helmet, and boots, but once you go to where the boots were supposed to be, you'll be informed that they are now in the Mendel Memorial library.
4. Once you become a Big Daddy, hit the vent with your wrench to call out a little sister.


Proving Grounds
1. Protect the little sister from the numerous splicers that keep on attacking her until she is safe.
2. Take the needle that she gives you and ride the elevator up to Fontaine.


Boss Fight: Fontaine
1. Fontaine has four bars of ADAM, drain the first from him as soon as the fight starts.
2. Wear down his health with everything in your arsenal, including your most power plasmids and guns.
3. Drain the second bar of ADAM from him and then attack Fontaine until his second life bar is no more.
4. Repeat this process and you should be able to beat Fontaine and complete the game.
5. Make sure you remember to heal yourself during this boss battle.